Mr Varghese took up his position as Secretary of the Department of Foreign Affairs and Trade on 3 December 2012.
Prior to this appointment, Mr Varghese was Australia’s High Commissioner to India from 2009 to 2012. Between 2004 and 2009, he was Director-General of the Office of National Assessments. Before that he was the Senior Adviser (International) to the Prime Minister. Mr Varghese was Australia's High Commissioner to Malaysia from 2000 to 2002. He has also served overseas in Tokyo (1994), Washington (1986-88) and Vienna (1980-83).
Mr Varghese has held a wide range of senior positions in the Department of Foreign Affairs and Trade in Canberra, including as Deputy Secretary (2002-2003), First Assistant Secretary of the International Security Division (1997), Head of the White Paper Secretariat (1996-97) which drafted Australia’s first white paper on foreign and trade policy, First Assistant Secretary of the Public Affairs Division (1994-96), and Assistant Secretary of Staffing (1991-92). He was seconded to the Department of the Prime Minister and Cabinet as First Assistant Secretary of the International Division (1998-1999).